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Patients with foot ulcers require specialized care to promote healing and prevent infection

Finally, at the 96th h, it was found that the expression of HO-1 reached at a minimum value, and the oxidative stress index (OSI) of fibroblasts was increased, collagen synthesis of fibroblasts was reduced, proliferation and migration were supressed, and apoptosis was increased (Li et al., 2018)

Sakamoto T, Imai H

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This process may lead to dysregulation of the HPA axiss negative feedback mechanism, triggering cortisol secretion disorders, further promoting stress responses and emotional disorders (Kmita et al., 2023)